- 专利标题： ANTIBODY VARIANT AND ISOFORM WITH LOWERED BIOLOGICAL ACTIVITY
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申请号： US16758128申请日： 2018-10-31
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公开(公告)号： US20200283544A1公开(公告)日： 2020-09-10
- 发明人: Kensaku Hosoguchi , Maki Kuwayama , Chifumi Seida , Yosuke Watanabe , Nobuyuki Tanaka , Satoshi Saitoh , Masakazu Fukuda
- 申请人： Chugai Seiyaku Kabushiki Kaisha
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4e4cc9c0
- 国际申请： PCT/JP2018/040436 WO 20181031
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; G01N33/68
摘要：
As antibody variants and isoforms having reduced FVIII mimetic activity than Emicizumab, the antibody variants having some specific amino acid residues in the variable region cleaved out and missing (Q-CDR-Clipped Variants) and the antibody isoforms having inter-heavy chain disulfide bonds less susceptible to reduction under mild reducing conditions (Protected Disulfide Isoforms) are provided.
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