- 专利标题: HETEROAROMATIC MDOULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA
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申请号: US16874961申请日: 2020-05-15
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公开(公告)号: US20200291010A1公开(公告)日: 2020-09-17
- 发明人: Alan Stuart JESSIMAN , Patrick Stephen JOHNSON , Kristoffer MAANSSON , Morten Dahl SØRENSEN
- 申请人: LEO PHARMA A/S
- 专利权人: Leo Pharma A/S
- 当前专利权人: Leo Pharma A/S
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@6f26687a
- 主分类号: C07D413/12
- IPC分类号: C07D413/12 ; C07D413/14 ; C07D417/14 ; C07D241/04
摘要:
The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.
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