A wireless mouse includes a mouse body and a wireless receiver. The wireless receiver is connected with a computer host. When the mouse body is operated by a user, an original information is generated. The original information is encrypted and converted into an encryption information by the mouse body. The wireless receiver receives the encryption information from the mouse body. After the encryption information is received by the wireless receiver, the encryption information is decrypted by the wireless receiver. Consequently, the encryption information is restored into the original information. After the computer host receives the original information through the wireless receiver, the computer host performs a corresponding operation.