发明申请
- 专利标题： METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLR2 ACTIVITY
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申请号： US15779595申请日： 2016-12-02
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公开(公告)号： US20200308235A1公开(公告)日： 2020-10-01
- 发明人: Stefan Haefner , Andreas Thywissen , Holger Hartmann , Nico Boehmer
- 申请人： BASF SE
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3943e1f3
- 国际申请： PCT/EP2016/079526 WO 20161202
- 主分类号： C07K14/37
- IPC分类号： C07K14/37 ; C12N9/16 ; C12N9/24 ; C12N15/80
摘要：
The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
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