- 专利标题： METHODS FOR OBTAINING REGULATORY T CELLS AND USES THEREOF
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申请号： US16899142申请日： 2020-06-11
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公开(公告)号： US20200308543A1公开(公告)日： 2020-10-01
- 发明人: Carole GUILLONNEAU , Ignacio ANEGON , Severine BEZIE
- 申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE NANTES , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@6f1fd0c
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; C12N5/0786 ; A61P37/06 ; A61K35/15 ; A61K35/17
摘要：
Disclosed is a method for obtaining a population of human Treg cells including the steps of: (a) culturing a population of human monocytes with a medium including an amount of an interleukin-34 (IL-34) polypeptide in order to obtain a population of immunosuppressive macrophages; (b) co-culturing a population of human peripheral blood mononuclear cells (PBMCs) and the population of immunosuppressive macrophages obtained at step (a).
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