- 专利标题： METHODS OF PRODUCING T CELL POPULATIONS USING P38 MAPK INHIBITORS
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申请号： US16754926申请日： 2018-10-10
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公开(公告)号： US20200316122A1公开(公告)日： 2020-10-08
- 发明人: Shashankkumar J. Patel , Nicholas P. Restifo
- 申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 当前专利权人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US2018/055206 WO 20181010
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C12N5/0783 ; A61P35/00
摘要：
Provided are methods of producing an isolated population of T cells for adoptive cell therapy, the method comprising culturing isolated T cells in vitro in the presence of a p38 mitogen activated protein kinase (p38 MAPK) inhibitor, wherein the T cells have antigenic specificity for a cancer antigen. Also provided are related isolated populations of T cells, pharmaceutical compositions, and methods of treating or preventing cancer in a mammal.
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