- 专利标题： SPECIFIC SITES FOR MODIFYING ANTIBODIES TO MAKE IMMUNOCONJUGATES
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申请号： US16701576申请日： 2019-12-03
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公开(公告)号： US20200338207A1公开(公告)日： 2020-10-29
- 发明人: Bernhard Hubert Geierstanger , Weijia Ou , Tetsuo Uno
- 申请人： Bernhard Hubert Geierstanger , Weijia Ou , Tetsuo Uno
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07K16/32
摘要：
The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.
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