Invention Application
- Patent Title: ANTI-CD40 ANTIBODIES AND USES THEREOF
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Application No.: US16958563Application Date: 2018-12-27
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Publication No.: US20200339700A1Publication Date: 2020-10-29
- Inventor: Bryan C. BARNHART , Brigitte DEVAUX , Aaron P. YAMNIUK , Shannon L. OKADA , Brenda L. STEVENS , James William WEST
- Applicant: Bristol-Myers Squibb Company , CytomX Therapeutics, Inc.
- Applicant Address: US NJ Princeton US CA South San Francisco
- Assignee: Bristol-Myers Squibb Company,CytomX Therapeutics, Inc.
- Current Assignee: Bristol-Myers Squibb Company,CytomX Therapeutics, Inc.
- Current Assignee Address: US NJ Princeton US CA South San Francisco
- International Application: PCT/US2018/067740 WO 20181227
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C12N15/63
Abstract:
Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
Public/Granted literature
- US11306149B2 Anti-CD40 antibodies and uses thereof Public/Granted day:2022-04-19
Information query
