- 专利标题: AUTOPHAGY MODULATORS FOR USE IN TREATING CANCER
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申请号: US16883046申请日: 2020-05-26
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公开(公告)号: US20200369649A1公开(公告)日: 2020-11-26
- 发明人: Melvin L. DePamphilis , Gaurav Sharma , Juan Jose Marugan , Marc Ferrer , Ajit Roy
- 申请人: The United States of America,as represented by the Secretary,Department of Health and Human Services
- 申请人地址: US MD Bethesda
- 专利权人: The United States of America,as represented by the Secretary,Department of Health and Human Services
- 当前专利权人: The United States of America,as represented by the Secretary,Department of Health and Human Services
- 当前专利权人地址: US MD Bethesda
- 主分类号: C07D403/12
- IPC分类号: C07D403/12 ; C07D251/54 ; C07D239/50 ; A61P35/00
摘要:
Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy-dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy-dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.
公开/授权文献
- US11471460B2 Autophagy modulators for use in treating cancer 公开/授权日:2022-10-18
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