A garment configured for detecting leakage from an absorbent article underlying the garment and methods of detecting leakage from an absorbent article using such a garment are disclosed. The garment can include a substrate and a wetness detection system. The wetness detection system can include a first wetness detection mechanism disposed at a first detection zone on the substrate. The wetness detection system can further include a second wetness detection mechanism disposed at a second detection zone on the substrate. The second detection zone can be different than the first detection zone. In preferred embodiments, the first wetness detection mechanism and the second wetness detection mechanism can be configured to sense wetness electronically.