- 专利标题： ANTI-CD277 ANTIBODIES AND USES THEREOF
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申请号： US16896556申请日： 2020-06-09
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公开(公告)号： US20200376104A1公开(公告)日： 2020-12-03
- 发明人: Daniel OLIVE , Marc BONNEVILLE , Emmanuel SCOTET , Christelle HARLY , Yves GUILLAUME
- 申请人： Daniel OLIVE , Marc BONNEVILLE , Emmanuel SCOTET , Christelle HARLY , Yves GUILLAUME
- 申请人地址： FR Paris FR Marseille Cedex 07 FR Marseille FR Paris FR Nantes
- 专利权人： Institut National de la Santé et de la Recherche Médicale (INSERM),UNIVERSITE D'AIX-MARSEILLE,INSTITUT JEAN PAOLI & IRENE CALMETTES,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),UNIVERSITE DE NANTES
- 当前专利权人： Institut National de la Santé et de la Recherche Médicale (INSERM),UNIVERSITE D'AIX-MARSEILLE,INSTITUT JEAN PAOLI & IRENE CALMETTES,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS),UNIVERSITE DE NANTES
- 当前专利权人地址： FR Paris FR Marseille Cedex 07 FR Marseille FR Paris FR Nantes
- 优先权： IBPCT/IB2010/003417 20101215
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/28
摘要：
Described herein are anti-CD277 antibodies which: activates or inhibit the cytolytic function of Vγ9/Vδ2 T cells, and/or costimulates T cells together with CD3-TCR, and/or costimulates T cells in addition to CD28-B7 costimulation, and/or increases the activity and/or survival of monocytes and dendritic cells. The use of said antibodies in therapy is also described.