The invention relates to a high-temperature and high-pressure nuclear magnetic resonance core holder. An inner cylinder body of the core holder is provided in an outer cylinder body, a nuclear magnetic resonance probe coil is provided between the outer cylinder body and the inner cylinder body, two plugging sleeves are respectively provided between both ends of the inner cylinder body and between both ends of the outer cylinder body, a sealing groove is provided at the inner side of each plugging sleeve, a sealing joint component is provided in each sealing groove of each plugging sleeve, and two ends of the nuclear magnetic resonance probe coil are respectively connected with the sealing joint component, so that the nuclear magnetic resonance probe coil can be led out. The holder disclosed by the invention is compatible with nuclear magnetic resonance, integrates injection displacement experiments and nuclear magnetic resonance measurement, and adopts a sealing solution to ensure the sealing performance of the joint of the outer cylinder body and the inner cylinder body, so as to adapt to nuclear magnetic resonance on-line measurement and analysis experiments under the condition of simulative deep basin high-temperature and high-pressure.