- 专利标题： ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
-
申请号： US16093804申请日： 2017-04-14
-
公开(公告)号： US20210017281A1公开(公告)日： 2021-01-21
- 发明人: Michael MOLLOY , Jay ROTHSTEIN , Catherine CARRIERE , Randolph J. NOELLE , Sabrina DELONG , Isabelle LEMERCIER
- 申请人： IMMUNEXT, INC. , THE TRUSTEES OF DARTMOUTH COLLEGE
- 申请人地址： US NH Lebanon; US NH Hanover
- 专利权人： IMMUNEXT, INC.,THE TRUSTEES OF DARTMOUTH COLLEGE
- 当前专利权人： IMMUNEXT, INC.,THE TRUSTEES OF DARTMOUTH COLLEGE
- 当前专利权人地址： US NH Lebanon; US NH Hanover
- 国际申请： PCT/US17/27800 WO 20170414
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61P19/02 ; A61P37/06 ; A61P17/06 ; A61P1/00 ; A61P1/16 ; A61K45/06 ; A61K39/395 ; A61P13/12
摘要：
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity. These agonist antibodies and antibody fragments are especially useful in the treatment of autoimmunity, allergy, inflammatory conditions, GVHD, sepsis and transplant recipients. Screening assays for identifying these agonists are also provided.
信息查询
