- 专利标题： Antibodies Binding to Vista at Acidic pH
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申请号： US16982277申请日： 2019-03-19
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公开(公告)号： US20210017283A1公开(公告)日： 2021-01-21
- 发明人: Robert J. Johnston , Arvind Rajpal , Paul O. Sheppard , Luis Borges , Andrew Rankin , Keith Sadoon Bahjat , Alan J. Korman , Xiaodi Deng , Lin Hui Su , Ginger Rakestraw , Jason R. Pinckney , David A. Critton , Guodong Chen , Richard Y. Huang , Ekaterina G. Deyanova
- 申请人： Five Prime Therapeutics, Inc. , Bristol-Myers Squibb Company
- 申请人地址： US CA South San Francisco; US NJ Princeton
- 专利权人： Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- 当前专利权人： Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- 当前专利权人地址： US CA South San Francisco; US NJ Princeton
- 国际申请： PCT/US2019/022895 WO 20190319
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/46 ; A61K38/16
摘要：
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
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