The present disclosure relates to a power supply grounding fault protection circuit. A power supply grounding fault protection circuit may include a power supply circuit, a leakage grounding detection circuit, a signal amplifying and shaping circuit, a microcontroller control circuit, a power supply detection and indicator circuit, a tripping mechanism control circuit, a reverse grounding detection and execution circuit, a wireless network circuit, and an automatic resetting circuit. The practice of the present disclosure may permit a user to reset the grounding fault circuit interrupter remotely after a leaking fault of a circuit is eliminated.