- 专利标题: CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
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申请号: US16934907申请日: 2020-07-21
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公开(公告)号: US20210040048A1公开(公告)日: 2021-02-11
- 发明人: Xiangping QIAN , Yong-Liang ZHU
- 申请人: NeuPharma, Inc.
- 申请人地址: US CA Foster City
- 专利权人: NeuPharma, Inc.
- 当前专利权人: NeuPharma, Inc.
- 当前专利权人地址: US CA Foster City
- 主分类号: C07D241/42
- IPC分类号: C07D241/42 ; C07D241/44 ; A61K31/5377 ; A61K31/498 ; C07D403/04 ; A61K45/06 ; A61P35/00 ; C07D401/12 ; C07D401/04
摘要:
Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically, quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.