Invention Application
- Patent Title: NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
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Application No.: US17094783Application Date: 2020-11-10
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Publication No.: US20210061849A1Publication Date: 2021-03-04
- Inventor: Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis
- Applicant: Sage Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Sage Therapeutics, Inc.
- Current Assignee: Sage Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Priority: CNPCT/CN2014/078820 20140529
- Main IPC: C07J43/00
- IPC: C07J43/00 ; C07J7/00 ; A61P25/14 ; A61P25/20 ; A61P25/18 ; A61P25/24 ; A61P25/08

Abstract:
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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