The present disclosure provides a method of positioning a patient. The patient is provided on a support surface, an inflatable positioning mattress disposed between the patient and the support surface. Air flow into the inflatable positioning mattress is initiated to inflate the inflatable positioning mattress. A downward force is applied on the inflatable positioning mattress proximate to a first side of the support surface. A portion of the inflatable positioning mattress proximate to a second side of the support surface is raised. At least one wedge is positioned beneath the inflatable positioning mattress. Subsequently, the patient is lowered onto the at least one wedge.