- 专利标题： COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ATYPICAL BRAF MUTATIONS
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申请号： US16613480申请日： 2018-05-15
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公开(公告)号： US20210085663A1公开(公告)日： 2021-03-25
- 发明人: Gary DeCrescenzo , Dean Welsch , Saurabh Saha
- 申请人： BIOMED VALLEY DISCOVERIES, INC.
- 申请人地址： US MO Kansas City
- 专利权人： BIOMED VALLEY DISCOVERIES, INC.
- 当前专利权人： BIOMED VALLEY DISCOVERIES, INC.
- 当前专利权人地址： US MO Kansas City
- 优先权： JP62506995 20170516
- 国际申请： PCT/US2018/032755 WO 20180515
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/506 ; A61K31/444 ; A61K31/5377 ; A61K31/4985 ; A61K38/48 ; A61K31/122 ; A61K31/4184 ; A61K31/4045 ; A61K31/365 ; A61K31/437 ; A61K31/675 ; A61K31/517 ; A61K31/44 ; C12N15/113 ; A61K31/519 ; A61K31/343 ; A61K31/325 ; A61K31/167 ; A61K31/166 ; A61K31/18 ; A61K45/06 ; A61K39/395 ; A61K31/131 ; A61K31/513 ; A61K31/198 ; A61K31/196 ; A61K31/175 ; A61K31/7028 ; A61K33/243 ; A61K38/45 ; A61K51/00 ; A61K38/21 ; A61K38/20 ; A61K38/19 ; A61K35/74 ; A61K31/4168 ; A61K31/4164 ; A61K31/53 ; A61K31/202 ; A61P35/00 ; C12Q1/6886
摘要：
The present invention provides, inter alia, methods, pharmaceutical compositions, and kits for treating or ameliorating the effects of a cancer in a subject, which harbors an atypical BRAF mutation (i.e. a non-V600E/K BRAF mutation), comprising an ERK inhibitor. Also provided are methods for identifying a subject having an atypical BRAF mutant cancer who would benefit from therapy comprising an ERK inhibitor.
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