- 专利标题： FC VARIANTS WITH REDUCED EFFECTOR FUNCTION
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申请号： US17024749申请日： 2020-09-18
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公开(公告)号： US20210087271A1公开(公告)日： 2021-03-25
- 发明人: Robert Pejchal , Eric Krauland , Maximiliano Vasquez , Michael Brown , Anthony Cooper
- 申请人： Adimab, LLC
- 申请人地址： US NH Lebanon
- 专利权人： Adimab, LLC
- 当前专利权人： Adimab, LLC
- 当前专利权人地址： US NH Lebanon
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
The present invention provides Fc variants and polypeptides, e.g., antibodies and Fc fusion proteins, comprising such Fc variants. In particular, Fc variants with diminished effector function as a consequence of hinge region and CH2 domain mutations, e.g., LALE-PG, are provided. Such variants maintain antigen-binding and favorable developability profiles and may display improved expressability.
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