Embodiments are presented herein of apparatuses, processors, systems, and methods for performing User Plane Integrity Protection handling procedures. A wireless device may establish a cellular link that provides access to a fifth generation core network. The wireless device may establish a protocol data unit session with a cellular network entity of the fifth generation core network. The wireless device may determine whether user plane integrity protection may be enabled for the protocol data unit session. The wireless device may perform one or more user plane integrity protection related modifications to the protocol data unit session.