发明申请
- 专利标题： ASTEXIN PEPTIDES
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申请号： US17128632申请日： 2020-12-21
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公开(公告)号： US20210107950A1公开(公告)日： 2021-04-15
- 发明人: A. James Link , Mikhail O. Maksimov
- 申请人： The Trustees of Princeton University
- 申请人地址： US NJ Princeton
- 专利权人： The Trustees of Princeton University
- 当前专利权人： The Trustees of Princeton University
- 当前专利权人地址： US NJ Princeton
- 主分类号： C07K14/195
- IPC分类号： C07K14/195 ; A01N63/10 ; A62D3/33 ; C02F1/28
摘要：
Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticaccaulis excentricus, and methods of making and using same.
Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticaccaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.