Implementations described and claimed herein provide systems and methods for isolation detection. In one implementation, an acoustic signal is obtained. The acoustic signal is captured at a set of acoustic receivers deployed in a structure in a subterranean surface. A differential acoustic signal is produced from the acoustic signal captured at the set of acoustic receivers. A symmetry within a portion of the structure is determined based on a value of the differential acoustic signal. At least one isolation region is detected within the structure based on the symmetry.