![Combinations of PD-1 Antagonists and Benzo[b]thiophene STING Agonists for Cancer Treatment](/docs/US/2021-05-06/US20210130466A1/abs.jpg.600x600.jpg)
- 专利标题： Combinations of PD-1 Antagonists and Benzo[b]thiophene STING Agonists for Cancer Treatment
-
申请号： US16635059申请日： 2018-07-30
-
公开(公告)号： US20210130466A1公开(公告)日： 2021-05-06
- 发明人: Saso CEMERSKI , Jared N. CUMMING , Johnny E. KOPINJA , Samanthi A. PERERA , Benjamin Wesley TROTTER , Archie Ngai-Chiu TSE
- 申请人： Saso CEMERSKI , Jared N. CUMMING , Johnny E. KOPINJA , Samanthi A. PERERA , Benjamin Wesley TROTTER , Archie Ngai-Chiu TSE , Merck Sharp & Dohme Corp.
- 申请人地址： US MA Boston; US MA Boston; US MA Boston; US MA Boston; US MA Boston; US NJ Rahway; US NJ Rahway
- 专利权人： Saso CEMERSKI,Jared N. CUMMING,Johnny E. KOPINJA,Samanthi A. PERERA,Benjamin Wesley TROTTER,Archie Ngai-Chiu TSE,Merck Sharp & Dohme Corp.
- 当前专利权人： Saso CEMERSKI,Jared N. CUMMING,Johnny E. KOPINJA,Samanthi A. PERERA,Benjamin Wesley TROTTER,Archie Ngai-Chiu TSE,Merck Sharp & Dohme Corp.
- 当前专利权人地址： US MA Boston; US MA Boston; US MA Boston; US MA Boston; US MA Boston; US NJ Rahway; US NJ Rahway
- 国际申请： PCT/US2018/044275 WO 20180730
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61P35/00 ; A61K31/381
![Combinations of PD-1 Antagonists and Benzo[b]thiophene STING Agonists for Cancer Treatment](/abs-image/US/2021/05/06/US20210130466A1/abs.jpg.150x150.jpg)
摘要：
Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one benzo[b]thiophene compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein. Also disclosed is the use of such therapeutic combinations for the treatment of cancers.
公开/授权文献
信息查询
