An electronic cleaning system and method includes a handle assembly configured to grasp a moistened tissue. A cartridge is included within a dispensing unit to store the tissue. A motor selectively releases the tissue from the cartridge. A control unit is configured to monitor and selectively control a plurality of devices that permit the hands-free cleaning and sanitizing of a defined area. The control unit processes and transmits data regarding the status of the defined area. A remote panel and auxiliary systems assist in cleaning and conveying information to users. The system permits for manually cleaning of surfaces in the defined area without the need to physically contact any of the cleaning tissue, chemicals, or surfaces therein. Additionally, the system includes UV light emitting systems to clean remote surfaces and the air. The user is separated from the potentially harmful surfaces and chemicals.