- 专利标题： ANALYSIS OF HLA ALLELES IN TUMOURS AND THE USES THEREOF
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申请号： US16628067申请日： 2018-07-13
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公开(公告)号： US20210147934A1公开(公告)日： 2021-05-20
- 发明人: Charles Swanton , Nicholas McGranahan , Rachel Rosenthal
- 申请人： THE FRANCIS CRICK INSTITUTE LIMITED , UNIVERSITY COLLEGE LONDON , CANCER RESEARCH TECHNOLOGY LIMITED
- 申请人地址： GB London; GB London; GB London
- 专利权人： THE FRANCIS CRICK INSTITUTE LIMITED,UNIVERSITY COLLEGE LONDON,CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人： THE FRANCIS CRICK INSTITUTE LIMITED,UNIVERSITY COLLEGE LONDON,CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人地址： GB London; GB London; GB London
- 优先权： GB1711349.9 20170714,GB1716079.7 20171002
- 国际申请： PCT/GB2018/052004 WO 20180713
- 主分类号： C12Q1/6881
- IPC分类号： C12Q1/6881 ; C12Q1/6886 ; A61K39/00 ; C12Q1/6869
摘要：
The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
公开/授权文献
- US11634773B2 Analysis of HLA alleles in tumours and the uses thereof 公开/授权日：2023-04-25
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