- 专利标题： METHOD FOR GENE TRANSFER INTO GAMMA-DELTA TYPE T CELL
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申请号： US17262900申请日： 2019-07-31
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公开(公告)号： US20210161963A1公开(公告)日： 2021-06-03
- 发明人: Hiroshi Shiku , Yoshihiro Miyahara , Satoshi Okumura , Takuma Kato , Tae Hayashi , Yoshimasa Tanaka
- 申请人： Mie University
- 申请人地址： JP Tsu-shi Mie
- 专利权人： Mie University
- 当前专利权人： Mie University
- 当前专利权人地址： JP Tsu-shi Mie
- 优先权： JP2018-143207 20180731
- 国际申请： PCT/JP2019/029999 WO 20190731
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K14/725 ; C12N5/0783 ; C12N15/85
摘要：
The present invention provides a method for efficiently producing highly pure γδT cells introduced with foreign genes by culturing in the presence of IL-7 and IL-15 after stimulating the γδT cells with a bisphosphonic acid ester derivative. When a T cell receptor (TCR) or a chimeric antigen receptor (CAR) is introduced as a foreign gene, γδT cells in which TCR and CAR are functionally expressed can be obtained.
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