Invention Application
- Patent Title: MODIFIED ANTIBODY AND RADIOACTIVE METAL-LABELLED ANTIBODY
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Application No.: US17047859Application Date: 2019-04-15
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Publication No.: US20210170058A1Publication Date: 2021-06-10
- Inventor: Shota KOMOTO , Yu OGAWA , Yoshinari SHOYAMA , Tadashi HATANO , Yuji ITO , Yasushi ARANO , Hiroyuki SUZUKI , Tomoya UEHARA
- Applicant: NIHON MEDI-PHYSICS CO., LTD. , National University Corporation Kagoshima University , National University Corporation Chiba University
- Applicant Address: JP Tokyo; JP Kagoshima-shi, Kagoshima; JP Chiba-shi, Chiba
- Assignee: NIHON MEDI-PHYSICS CO., LTD.,National University Corporation Kagoshima University,National University Corporation Chiba University
- Current Assignee: NIHON MEDI-PHYSICS CO., LTD.,National University Corporation Kagoshima University,National University Corporation Chiba University
- Current Assignee Address: JP Tokyo; JP Kagoshima-shi, Kagoshima; JP Chiba-shi, Chiba
- Priority: JP2018-078487 20180416
- International Application: PCT/JP2019/016156 WO 20190415
- Main IPC: A61K51/10
- IPC: A61K51/10 ; A61K51/08 ; A61K51/04 ; C07K7/08 ; C07D257/02 ; C07K16/32

Abstract:
The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.
Public/Granted literature
- US11701440B2 Modified antibody and radioactive metal-labelled antibody Public/Granted day:2023-07-18
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