- 专利标题: NOVEL ANTIBODY FORMAT
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申请号: US17177543申请日: 2021-02-17
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公开(公告)号: US20210171619A1公开(公告)日: 2021-06-10
- 发明人: Stefan DENGL , Peter Michael HUELSMANN
- 申请人: Hoffmann-La Roche Inc.
- 申请人地址: US NJ Little Falls
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Little Falls
- 优先权: EP16177746.1 20160704
- 主分类号: C07K16/22
- IPC分类号: C07K16/22 ; A61P27/02 ; A61P9/00 ; C07K16/24
摘要:
Herein is reported a recombinant fusion polypeptide comprising an antibody heavy chain variable domain, a multimerization domain and an antibody light chain variable domain, wherein the antibody heavy chain variable domain is fused (either directly or via a first (peptidic) linker) to one terminus of the multimerization domain, the antibody light chain variable domain is fused (either directly or via a second (peptidic) linker) to the respective other terminus of the multimerization domain, and the antibody heavy chain variable domain or the antibody light chain variable domain has a (intra-peptidic) disulphide bond to the multimerization domain.
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