Methods and systems are provided for determining diagnostic-scan parameters for a magnetic resonance (MR) diagnostic-scan, from MR calibration images, enabling acquisition of high-resolution diagnostic images of one or more anatomical regions of interest, while bypassing acquisition of localizer images, increasing a speed and efficiency of MR diagnostic-scanning. In one embodiment, a method for a magnetic resonance imaging (MRI) system comprises, acquiring a magnetic resonance (MR) calibration image of an imaging subject, mapping the MR calibration image to a landmark map using a trained deep neural network, determining one or more diagnostic-scan parameters based on the landmark map, acquiring an MR diagnostic image according to the diagnostic-scan parameters, and displaying the MR diagnostic image via a display device.