- 专利标题： ANTI-MUC1 ANTIBODY-DRUG CONJUGATE
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申请号： US17055323申请日： 2019-05-17
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公开(公告)号： US20210187118A1公开(公告)日： 2021-06-24
- 发明人: Johanna GELLERT , Anke FLECHNER , Doreen WEIGELT , Antje DANIELCZYK , Akiko NAGASE
- 申请人： DAIICHI SANKYO CO., LTD.
- 申请人地址： JP Tokyo
- 专利权人： DAIICHI SANKYO CO., LTD.
- 当前专利权人： DAIICHI SANKYO CO., LTD.
- 当前专利权人地址： JP Tokyo
- 优先权： EP18173253.8 20180518
- 国际申请： PCT/EP2019/062758 WO 20190517
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07K16/30 ; A61K31/4745 ; A61K47/54 ; A61K47/65 ; A61P35/00
摘要：
The present disclosure relates to antibody drug conjugates directed against the cancer antigen MUC1. In particular, an antibody with improved antigen binding was obtained by deleting a glycosylation site in the CDR-H2 of a known anti-MUC1 antibody. The conjugates consist of exatecan derivatives coupled to the anti MUC1 antibodies.
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