Invention Application
- Patent Title: ARTIFICIAL NUCLEOSIDE AND ARTIFICIAL NUCLEOTIDE, AND ARTIFICIAL OLIGONUCLEOTIDE
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Application No.: US16077969Application Date: 2017-02-17
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Publication No.: US20210188894A1Publication Date: 2021-06-24
- Inventor: Kohji SEIO , Yoshiaki MASAKI , Keishi YAMAMOTO , Keita YOSHIDA , Yusuke IRIYAMA , Hiroyuki NAKAJIMA , Tatsuro KANAKI
- Applicant: TOKYO INSTITUTE OF TECHNOLOGY , NISSAN CHEMICAL CORPORATION
- Applicant Address: JP Tokyo; JP Tokyo
- Assignee: TOKYO INSTITUTE OF TECHNOLOGY,NISSAN CHEMICAL CORPORATION
- Current Assignee: TOKYO INSTITUTE OF TECHNOLOGY,NISSAN CHEMICAL CORPORATION
- Current Assignee Address: JP Tokyo; JP Tokyo
- Priority: JP2016-028109 20160217,JP2016-211476 20161028
- International Application: PCT/JP2017/005835 WO 20170217
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H19/067

Abstract:
Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).
Public/Granted literature
- US11384112B2 Artificial nucleoside and artificial nucleotide, and artificial oligonucleotide Public/Granted day:2022-07-12
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