- 专利标题： POLYPEPTIDES FOR PREPARING DRUG CONJUGATES CAPABLE OF PROMOTING APOPTOSIS IN A CELL EXPRESSING AN OREXIN RECEPTOR
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申请号： US16077946申请日： 2017-02-17
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公开(公告)号： US20210188983A1公开(公告)日： 2021-06-24
- 发明人: Bruno ROBERT , Pierre MARTINEAU , Alain COUVINEAU
- 申请人： UNIVERSITE DE MONTPELLIER , INSTITUT REGIONAL DU CANCER DE MONTPELLIER , UNIVERSITE PARIS DIDEROT - PARIS 7
- 专利权人： UNIVERSITE DE MONTPELLIER,INSTITUT REGIONAL DU CANCER DE MONTPELLIER,UNIVERSITE PARIS DIDEROT - PARIS 7
- 当前专利权人： UNIVERSITE DE MONTPELLIER,INSTITUT REGIONAL DU CANCER DE MONTPELLIER,UNIVERSITE PARIS DIDEROT - PARIS 7
- 优先权： EP16305187.3 20160218
- 国际申请： PCT/EP2017/053616 WO 20170217
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K47/68
摘要：
The present invention relates to polypeptides for preparing drug conjugates capable of promoting apoptosis in a cell expressing an orexin receptor. In particular, the present invention relates to a polypeptide comprising the amino acid sequence of formula of X20-X21-X22-X23-G-X25-L-X27-X28 wherein: —X20 represents N, D, or K, —X21 represents H, A or Q, —X22 represents A, S, T or G, —X23 represents A, T or G, —X25 represents I or L, —X27 represents T or V and, —X28 represents M, L, V, Y or I.
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