- 专利标题： ENGINEERED ACID ALPHA-GLUCOSIDASE VARIANTS
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申请号： US17126647申请日： 2020-12-18
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公开(公告)号： US20210189365A1公开(公告)日： 2021-06-24
- 发明人: William Casey Hallows , Rachel Cathleen Botham , Yu Zhu , Chinping Chng , Nikki Dellas , Gjalt W. Huisman , Moulay Hicham Alaoui Ismaili , David William Homan , Adam P. Silverman , Jonathan Vroom , Jessica P. Lao
- 申请人： Codexis, Inc.
- 申请人地址： US CA Redwood City
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： US CA Redwood City
- 主分类号： C12N9/34
- IPC分类号： C12N9/34
摘要：
The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.
公开/授权文献
- US11970722B2 Engineered acid alpha-glucosidase variants 公开/授权日：2024-04-30
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