- 专利标题： SPR-BASED BRIDGING ASSAY FORMAT FOR DETERMINING THE BIOLOGICAL ACTIVITY OF MULTIVALENT, MULTISPECIFIC MOLECULES
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申请号： US16998990申请日： 2020-08-20
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公开(公告)号： US20210199666A1公开(公告)日： 2021-07-01
- 发明人: Apollon Papadimitriou , Joerg Thomas Regula , Hubert Kettenberger , Joerg Moelleken , Christian Gassner
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 优先权： EP13197264.8 20131213
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; G01N33/543 ; G01N21/65
摘要：
Herein is reported the use of a binding assay of a bivalent, bispecific antibody that has the smaller kD value (dissociation constant) for the interaction with its antigen for the immobilization of the bivalent, bispecific antibody to a solid surface for the determination of the biological activity of the bivalent, bispecific antibody.
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