- 专利标题： NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (hDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION
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申请号： US16972456申请日： 2019-06-06
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公开(公告)号： US20210230156A1公开(公告)日： 2021-07-29
- 发明人: Donatella BOSCHI , Marta GIORGIS , Marco Lucio LOLLI , Giovanni MARTINELLI , Giuseppe SAGLIO
- 申请人： Donatella BOSCHI , Marta GIORGIS , Marco Lucio LOLLI , Giovanni MARTINELLI , Giuseppe SAGLIO
- 申请人地址： IT Torino; IT Torino; IT Torino; IT Mozzecane (Verona); IT Torino
- 专利权人： Donatella BOSCHI,Marta GIORGIS,Marco Lucio LOLLI,Giovanni MARTINELLI,Giuseppe SAGLIO
- 当前专利权人： Donatella BOSCHI,Marta GIORGIS,Marco Lucio LOLLI,Giovanni MARTINELLI,Giuseppe SAGLIO
- 当前专利权人地址： IT Torino; IT Torino; IT Torino; IT Mozzecane (Verona); IT Torino
- 优先权： IT102018000006067 20180606
- 国际申请： PCT/EP2019/064861 WO 20190606
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61P35/02 ; A61P35/00
摘要：
Compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH) and pharmaceutical compositions containing the compounds of formulae (I) and (II) are provided. A method for treating tumor diseases, including acute myelogenous leukemia (AML), triple-negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors by administering pharmaceutical compositions containing the compounds of formulae (I) and (II) is also provided.
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