- 专利标题： CHIMERIC ANTIGEN RECEPTOR TARGETING SIALYL LEWIS A AND USES THEREOF
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申请号： US17233994申请日： 2021-04-19
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公开(公告)号： US20210246221A1公开(公告)日： 2021-08-12
- 发明人: Michel Sadelain , David J. Hansen
- 申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , BIONTECH RESEARCH AND DEVELOPMENT, INC.
- 申请人地址： US NY New York; US MA Cambridge
- 专利权人： MEMORIAL SLOAN-KETTERING CANCER CENTER,BIONTECH RESEARCH AND DEVELOPMENT, INC.
- 当前专利权人： MEMORIAL SLOAN-KETTERING CANCER CENTER,BIONTECH RESEARCH AND DEVELOPMENT, INC.
- 当前专利权人地址： US NY New York; US MA Cambridge
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; C07K14/725 ; C07K14/705 ; A61K35/17 ; A61P35/00
摘要：
The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., pancreatic cancer). It relates to antigen recognizing receptor (e.g., chimeric antigen receptors (CARs)) that specifically target Sialyl Lewis A (e.g., human Sialyl Lewis A), and immunoresponsive cells comprising such CARs. The presently disclosed Sialyl Lewis A-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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