Example implementations relate to application-specific policies for failing over from an edge site to a cloud. When an application becomes operational within an edge site, a discovery phase is performed by a local disaster recovery (DR) agent. I/O associated with a workload of the application is monitored. An I/O rate for data replication that satisfies latency characteristics of the application is predicted based on the incoming I/O. Based on results of tests against multiple clouds indicative of their respective RTO/RPO values, information regarding a selected cloud to serve as a secondary system is stored in an application-specific policy. The application-specific policy is transferred to a remote DR agent running in the selected cloud. Responsive to a failover event, infrastructure within a virtualized environment of the selected cloud is enabled to support a failover workload for the application based on the application-specific policy.