- 专利标题： AZITHROMYCIN DERIVATIVES CONTAINING A PHOSPHONIUM ION AS ANTICANCER AGENTS
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申请号： US16606340申请日： 2018-04-20
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公开(公告)号： US20210253616A1公开(公告)日： 2021-08-19
- 发明人: Tim Sparey , Andrew Ratcliffe , Brett Stevenson , Franz Lagasse , Edward Cochrane
- 申请人： Rising Tide Foundation
- 申请人地址： CH Schaffhausen
- 专利权人： Rising Tide Foundation
- 当前专利权人： Rising Tide Foundation
- 当前专利权人地址： CH Schaffhausen
- 优先权： GB1706309.0 20170420,GB1721752.2 20171222
- 国际申请： PCT/EP2018/060245 WO 20180420
- 主分类号： C07F9/6568
- IPC分类号： C07F9/6568 ; C07F9/54
摘要：
This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.