- 专利标题： KRAS G12C INHIBITORS
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申请号： US16099398申请日： 2017-05-17
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公开(公告)号： US20210269432A1公开(公告)日： 2021-09-02
- 发明人: John P. FISCHER , Jay Bradford FELL , James F. BLAKE , Ronald Jay HINKLIN , Macedonio J. MEJIA , Erik James HICKEN , Mark Joseph CHICARELLI , John J. GAUDINO , Guy P.A. VIGERS , Laurence E. BURGESS , Matthew Arnold MARX , James Gail CHRISTENSEN , Matthew Randolf LEE , Pavel SAVECHENKOV , Henry J. ZECCA , Tony P. TANG
- 申请人： MIRATI THERAPEUTICS, INC. , ARRAY BIOPHARMA INC.
- 申请人地址： US CA San Diego; US CO Boulder
- 专利权人： MIRATI THERAPEUTICS, INC.,ARRAY BIOPHARMA INC.
- 当前专利权人： MIRATI THERAPEUTICS, INC.,ARRAY BIOPHARMA INC.
- 当前专利权人地址： US CA San Diego; US CO Boulder
- 国际申请： PCT/US2017/033099 WO 20170517
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D519/00 ; A61P35/00
摘要：
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
公开/授权文献
- US11267812B2 KRAS G12C inhibitors 公开/授权日：2022-03-08
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