- 专利标题： MACROCYCLIC CHLORINE SUBSTITUTED INDOLE DERIVATIVES
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申请号： US16764675申请日： 2018-11-15
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公开(公告)号： US20210277022A1公开(公告)日： 2021-09-09
- 发明人: Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Katrin Nowak-Reppel , Jeremie Xavier Mortier , Patrick Ryan McCarren , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Rebecca Ann Flarvey , Daniel Payne , Thomas Pesnot , Craig Wilson
- 申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc.
- 申请人地址： DE Leverkusen; DE Berlin; US MA Cambridge
- 专利权人： Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.
- 当前专利权人： Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.
- 当前专利权人地址： DE Leverkusen; DE Berlin; US MA Cambridge
- 国际申请： PCT/EP2018/081388 WO 20181115
- 主分类号： C07D498/14
- IPC分类号： C07D498/14 ; C07D487/14 ; A61K45/06
摘要：
The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
公开/授权文献
- US11447504B2 Macrocyclic chlorine substituted indole derivatives 公开/授权日：2022-09-20
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