- 专利标题: SYNTHESIS METHOD FOR CARIPRAZINE
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申请号: US17266955申请日: 2019-08-06
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公开(公告)号: US20210300883A1公开(公告)日: 2021-09-30
- 发明人: Wenjing LIAO , Jianfeng GE , Jicheng ZHANG , Luning HUANG , Anping TAO , Eric GU
- 申请人: Zhejiang Huahai Pharmaceutical Co., Ltd , SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.
- 申请人地址: CN Zhejiang; CN Shanghai
- 专利权人: Zhejiang Huahai Pharmaceutical Co., Ltd,SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.
- 当前专利权人: Zhejiang Huahai Pharmaceutical Co., Ltd,SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.
- 当前专利权人地址: CN Zhejiang; CN Shanghai
- 优先权: CN201810993813.3 20180829
- 国际申请: PCT/CN2019/099374 WO 20190806
- 主分类号: C07D295/135
- IPC分类号: C07D295/135
摘要:
The present application relates to a synthesis method for cariprazine, comprising performing an acylation reaction between a compound represented by formula (I) and dimethylcarbamoyl chloride in a reaction solvent in the presence of an aqueous solution of an inorganic base, so as to obtain the cariprazine compound represented by formula (II). The synthesis method overcomes defects in the prior art such as a long reaction time, large size impurities and the difficulty of purification, and provides a new method suitable for commercial production wherein the reaction is fast, impurity sizes are small, the product is easily purified, the purity of the product can reach 99.0% or more, and the yield is high.
公开/授权文献
- US11420948B2 Synthesis method for cariprazine 公开/授权日:2022-08-23
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