Provided are a method and apparatus for determining a rescue plan, a server, and a storage medium. The method includes obtaining target locations of one or more rescue targets and hospital locations of one or more hospitals, determining rescue-center locations of one or more rescue centers based on the target locations and the hospital locations, and determining a rescue plan for rescuing the one or more rescue targets based on the target locations, the hospital locations, and the rescue-center locations. This method achieves the effect of automatically generating a rescue plan in response to a disaster event.