Various examples of device and system implementations and methods for performing end-to-end attestation operations for multi-layer hardware devices are disclosed. In an example, attestation operations are performed by a verifier, including: obtaining layered attestation evidence regarding a state of a compute device, with the layered attestation evidence including attesting evidence provided from a second hardware layer of the compute device, such that the attesting evidence provided from the second hardware layer is generated from attesting evidence provided from a first hardware layer of the compute device to the second hardware layer of the compute device; obtaining endorsement information relating to the layered attestation evidence for the state of the compute device; determining an appraisal policy for performing attestation of the compute device from the layered attestation evidence; and applying the appraisal policy and the endorsement information to the layered attestation evidence, to perform attestation of the compute device.