A high-strength steel sheet of the present invention has a specific chemical composition. Furthermore, in the steel sheet, a degree of Mn segregation in a specific region is 1.5 or less; a maximum P concentration in a specific region is 0.08 mass % or less; in a specific region, the number of specific MnS particle groups is 2.0 or fewer per 1 mm2, and the number of specific oxide-based inclusions is 8 or fewer per 1 mm2; of all of the oxide-based inclusions, oxide-based inclusions having a specified composition are present in a number ratio of 80% or greater; the microstructure includes, in terms of a volume fraction, 30 to 95% martensite and bainite in total, 5 to 70% ferrite phase, and less than 3% (and 0% or greater) austenite phase; and a tensile strength is 980 MPa or greater.