- 专利标题： METHODS FOR TREATING CANCER OR INFECTION USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY, AN ANTI-LAG3 ANTIBODY, AND AN ANTI-TIGIT ANTIBODY
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申请号： US16966100申请日： 2019-01-31
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公开(公告)号： US20210363243A1公开(公告)日： 2021-11-25
- 发明人: Mingmei Cai , Rene de Waal Malefyt , Laurence Fayadat-Dilman , Ying Li , Ruban Mangadu , Uyen Phan
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US19/15936 WO 20190131
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61P35/00
摘要：
Provided herein are methods of treating cancer or infection, which comprise administering to a human patient in need thereof: (a) an anti-human PD-1 monoclonal antibody or antigen binding fragment thereof; (b) an anti-human LAG3 monoclonal antibody or antigen binding fragment thereof; and (c) an anti-human TIGIT monoclonal antibody or antigen binding fragment thereof. Also provided are pharmaceutical compositions and kits containing such agents for the treatment of cancer or infection.
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