- 专利标题： PREPARATION OF N-MONOFLUOROALKYL COMPOUNDS
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申请号： US17174155申请日： 2021-02-11
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公开(公告)号： US20220009919A1公开(公告)日： 2022-01-13
- 发明人: Lorenzo Williams , Gunnar Keilen , Jarle Andre Haugan
- 申请人： GE Healthcare Limited
- 申请人地址： GB Buckinghamshire
- 专利权人： GE Healthcare Limited
- 当前专利权人： GE Healthcare Limited
- 当前专利权人地址： GB Buckinghamshire
- 优先权： GB0922023.7 20091217
- 主分类号： C07D451/02
- IPC分类号： C07D451/02 ; C07F7/00 ; C07F7/22
摘要：
The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodide. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the 123I-labelled radiopharmaceutical DaTSCAN™ (123I-ioflupane). Also provided is the use of fluoroalkyl iodide in the alkylation method of the invention.
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