Various embodiments disclosed relate to a system and methods for hemodialysis, including detachable sorbent cartridge canisters. The present disclosure can include a system for hemodialysis having a first dialysis module including a dialyzer, a blood circuit configured to receive blood from a patient, circulate the blood through the dialyzer, and return cleaned blood to the patient, a dialysate circuit configured to circulate dialysate through the dialyzer and remove impurities from the blood, and a first canister detachably coupled to dialysate circuit, the canister comprising a first sorbent.