A system and method for generating and processing preambles in wireless communication are disclosed herein. In one embodiment, the system and method are configured to receive, from a wireless communication node, a message indicating a first sequence configuration including a set of predefined parameters and a second sequence configuration including a plurality of sets of parameters; generate a first part of a random access preamble based on the set of predefined parameters; generate a second part of the random access preamble based on selecting one of the plurality of sets of parameters; and transmit the random access preamble to the wireless communication node, wherein the first part is configured to be used by the wireless communication node to locate the second part in a time domain.