Invention Application
- Patent Title: HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS
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Application No.: US17293157Application Date: 2019-11-15
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Publication No.: US20220023281A1Publication Date: 2022-01-27
- Inventor: Gareth RICHARDS , Timothy M. SKERRY , Joseph P.A. HARRITY , Jean-Olivier ZIRIMWABAGABO , Matthew J. TOZER , Karl Richard GIBSON , Roderick Alan PORTER , Paul Alan GLOSSOP
- Applicant: THE UNIVERSITY OF SHEFFIELD
- Applicant Address: GB Sheffield, South Yorkshire
- Assignee: THE UNIVERSITY OF SHEFFIELD
- Current Assignee: THE UNIVERSITY OF SHEFFIELD
- Current Assignee Address: GB Sheffield, South Yorkshire
- Priority: GB1818651.0 20181115
- International Application: PCT/GB2019/053236 WO 20191115
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; A61P35/00 ; C07D471/10 ; C07D519/00 ; A61K31/496 ; A61K31/437 ; A61K31/55 ; A61K31/439 ; A61K45/06 ; A61N5/10

Abstract:
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein HET, R1, R2, R3, R4, R5, L, L1, X1, X2, X3 and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.
Information query
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